Abstract | OBJECTIVE: To compare the clinical efficacy and safety of high-dose (5 mg/day) and low-dose (2.5 mg/day) finasteride in the treatment of hirsutism in women. DESIGN: A prospective, randomized and controlled clinical trial. METHODS: RESULTS: The hirsutism scores decreased significantly at months 6 and 12 from a mean+/-s.d. of 18.4+/-4.6 to 13.3+/-5.2 (P<0.001) and 18.4+/-4.6 to 8.6+/-4.2 (P<0.001) in group I and from 18.7+/-5.2 to 13.9+/-5.3 (P<0.001) and 18.7+/-5.2 to 10.3+/-5.0 (P<0.001) in group II respectively. No significant changes in the blood chemistry and hormonal parameters except estradiol levels were observed. No serious side-effects were seen in the two groups. In group II, estradiol levels increased significantly at 6 and 12 months. CONCLUSIONS: In this study, hirsutism scores decreased significantly at 6 and 12 months in both groups I and II. Low-dose (2.5 mg/day) finasteride is safe and cost effective in the treatment of hirsutism and may be used instead of high-dose finasteride (5 mg/day) therapy.
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Authors | Fahri Bayram, I Ipek Müderris, Muhammed Güven, Fahrettin Keleştimur |
Journal | European journal of endocrinology
(Eur J Endocrinol)
Vol. 147
Issue 4
Pg. 467-71
(Oct 2002)
ISSN: 0804-4643 [Print] England |
PMID | 12370107
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Enzyme Inhibitors
- Sex Hormone-Binding Globulin
- Testosterone
- Androstenedione
- Estradiol
- Dehydroepiandrosterone Sulfate
- Finasteride
- 17-alpha-Hydroxyprogesterone
- Luteinizing Hormone
- Follicle Stimulating Hormone
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Topics |
- 17-alpha-Hydroxyprogesterone
(blood)
- Adolescent
- Adult
- Androstenedione
(blood)
- Dehydroepiandrosterone Sulfate
(blood)
- Enzyme Inhibitors
(administration & dosage)
- Estradiol
(blood)
- Female
- Finasteride
(administration & dosage)
- Follicle Stimulating Hormone
(blood)
- Hirsutism
(blood, drug therapy)
- Humans
- Luteinizing Hormone
(blood)
- Sex Hormone-Binding Globulin
(metabolism)
- Testosterone
(blood)
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