Abstract | PURPOSE: The results of previous studies of colorectal neoplasia and fecal composition have been inconsistent, in part because the cases have been symptomatic and the studies small. We sought to test hypotheses relating to fecal bile acids, calcium, and pH in a large sample of asymptomatic subjects who had participated in fecal occult blood screening. METHODS: Fecal samples were obtained from 45 cases of cancer, 129 subjects with adenoma, 167 fecal occult blood-negative controls and 155 fecal occult blood-positive subjects in whom no cancer or adenoma was found. Concentrations of fecal bile acids, steroids, calcium, and pH were assessed blind to case-control status and compared between cases and 1) fecal occult blood-negative controls and 2) fecal occult blood-positive subjects. RESULTS: CONCLUSION:
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Authors | Julian Little, Robert W Owen, Fresie Fernandez, Patricia G Hawtin, Michael J Hill, Richard F A Logan, Michael H Thompson, Jack D Hardcastle |
Journal | Diseases of the colon and rectum
(Dis Colon Rectum)
Vol. 45
Issue 9
Pg. 1233-41
(Sep 2002)
ISSN: 0012-3706 [Print] United States |
PMID | 12352242
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adenoma
(diagnosis, epidemiology, metabolism)
- Aged
- Bile Acids and Salts
(analysis)
- Carcinoma
(diagnosis, epidemiology, metabolism)
- Case-Control Studies
- Colorectal Neoplasms
(diagnosis, epidemiology, metabolism)
- England
(epidemiology)
- Feces
(chemistry)
- Female
- Humans
- Hydrogen-Ion Concentration
- Logistic Models
- Male
- Middle Aged
- Occult Blood
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