[Clinical effects of moderate and high doses of carpipramine (author's transl)].

An open trial of Carpipramine which chemically is a synthesis of a tricyclic antidepressant and the side chain of a butyrophrenone has been performed in 75 acute and chronic schizophrenics over a period of 30 days. The daily dose was 400-800 mg exeeding the recommendations of the manufacturer. The psychopathological changes were documented and evaluated by means of the AMP and the AMPAS-system. In 50 of the patients the trial could be completed. Only the productive symptoms and disturbance of sleep showed a significantly decreased frequency before day 10. It seems remarkable that the symptom of somatic hallucinations responded very rapidly under treatment with Carpipramine. Significant sedative or extrapyramidal side-effects were not observed; anticholinergic effects were moderate. There seems to be evidence of a slight centrally stimulating component. The substance cnnot be classified as a typical neuroleptic nor as an antidepressant drug. A differential action depending on the initial syndrome constellation is discussed.
AuthorsD Athen, D Bente, V Bikadorow, J Feder, B Müller-Oerlinghausen
JournalPharmakopsychiatrie, Neuro-Psychopharmakologie (Pharmakopsychiatr Neuropsychopharmakol) Vol. 8 Issue 5 Pg. 269-309 (Sep 1975) ISSN: 0031-7098 [Print] GERMANY, WEST
Vernacular TitleDas klinische Wirkungsspektrum mittlerer und hoher Dosen von Carpipramin
PMID1233521 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antidepressive Agents, Tricyclic
  • Dibenzazepines
  • Piperidines
  • Acute Disease
  • Antidepressive Agents, Tricyclic (administration & dosage, therapeutic use)
  • Chronic Disease
  • Dibenzazepines (administration & dosage, therapeutic use)
  • Drug Evaluation
  • Humans
  • Piperidines (administration & dosage, therapeutic use)
  • Schizophrenia (drug therapy)

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