[Cellular fibroma of the ovary: description of a case].

Abstract

Cellular fibromas of the ovary are rare neoplasms belonging to the group of sex-cord stromal tumours. They have been described to show from 1 to 3 mitotic figures per 10 high power fields (HPF) and they generally behave in a benign fashion. Herein we describe the clinicopathological features of a case of ovarian cellular fibroma. The patient, a 22-year-old woman, presented with acute abdominal pain. Laparotomy revealed a large ovarian mass. Histologically the lesion was composed of spindle cells showing slight or moderate pleomorphism and 3 mitoses per 10 HPF. The spindle cells were immunoreactive for vimentin, smooth muscle actin and inhibin alpha-subunit. The differential diagnoses that we considered included the mitotically active leiomyoma because of the strong positivity for smooth muscle actin, but positive immunoreaction with anti alpha-inhibin antibody helped in confirming a sex-cord stromal tumour. Electron microscopy did not show any evidence of smooth muscle differentiation.

• Authors: M Zanelli, S Cortecchia, S Folicaldi, G Pasquinelli, A Bondi
• Journal: Pathologica (Pathologica) Vol. 94 Issue 4 Pg. 196-200 (Aug 2002) ISSN: 0031-2983 [Print] Italy
• Vernacular Title: Fibroma cellulato dell'ovaio: descrizione di un caso.
• PMID: 12325418 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Actins
• Biomarkers, Tumor
• Neoplasm Proteins
• Vimentin
• inhibin-alpha subunit
• Inhibins

Topics

• Actins (analysis)
• Adult
• Biomarkers, Tumor (analysis)
• Cell Differentiation
• Cell Nucleus (ultrastructure)
• Diagnosis, Differential
• Female
• Fibroma (chemistry, classification, surgery, ultrastructure)
• Humans
• Inhibins (analysis)
• Leiomyoma (diagnosis)
• Microscopy, Electron
• Mitotic Index
• Neoplasm Proteins (analysis)
• Ovarian Neoplasms (chemistry, surgery, ultrastructure)
• Sex Cord-Gonadal Stromal Tumors (chemistry, classification, surgery, ultrastructure)
• Vimentin (analysis)