[Studies on the relation between the production of anti-O and anti-H agglutinins and the specific treatment of typhoid fever].

Abstract

The AA, studied the behaviour of anti-O and anti-H agglutinins in patients with typhoid fever treated with CAF or with CAF+ corticosteroides. They have shown that, during the treatment with antibiotics, the O-agglutinins, which appeared extremely quickly, can be present at a high level and for a long time in the serum; on the other hand the H-agglutinins are usually present at a lower level and tend to decrease more rapidly. In patients treated with CAF+ corticosteroides the agglutinins behaviour was not substancially different from that in patients treated with antibiotic only. These modifications in humoral immunity are notable only when treatment is begun early. On the basis of the results and of data in the most recent literature, the AA. also discuss the problem of typhoid relapses, the pathogenesis of which cannot depend from the modifications of humoral immunity only.

• Authors: B Ferlazzo, R Ricciardi, A Barrile
• Journal: Annali Sclavo; rivista di microbiologia e di immunologia (Ann Sclavo) 1975 Nov-Dec Vol. 17 Issue 6 Pg. 803-16 Italy
• Vernacular Title: Studio dei rapporti tra produzione di agglutinine anti-O e anti-H e trattamento specifico della febbre tifoide
• PMID: 1230059 (Publication Type: English Abstract, Journal Article)

Chemical References

• Agglutinins
• Chloramphenicol

Topics

• Adolescent
• Adult
• Agglutinins
• Antibody Formation (drug effects)
• Chloramphenicol (pharmacology, therapeutic use)
• Female
• Humans
• Male
• Middle Aged
• Typhoid Fever (drug therapy, immunology)