[In vivo action of valinomycin on Ehrlich ascites tumor cells. Inhibition of the proliferative activity of the tumor cells under the action of valinomycin].

Abstract

It was shown that repeated administrations of valinomycin in doses of 1.0 and 0.01 gamma/gm to mice with Ehrlich ascitic tumors inhibited the ascite development. The radioautographic study using 3H-thimidine showed that 24 hours after the administration of valinomycin in doses of 0.1 and 0.01 gamma/gm transference of the cells into the phase of DNA synthesis was inhibited--inhibition of the tumor cell mitotic activity took place.

• Authors: I B Sorokina, L A Mingareeva, V M Manteĭfel'
• Journal: Antibiotiki (Antibiotiki) Vol. 20 Issue 8 Pg. 701-5 (Aug 1975) ISSN: 0003-5637 [Print] Russia (Federation)
• Vernacular Title: Deĭstvie valinomitsina in vivo na kletki astsitnoĭ opukholi Erlikha. Tormozhenie proliferativnoĭ aktivnosti opukholevykh kletok pod vliianiem valinomitsina
• PMID: 1229994 (Publication Type: English Abstract, Journal Article)

Chemical References

• DNA, Neoplasm
• Tritium
• Valinomycin
• Thymidine

Topics

• Animals
• Body Weight (drug effects)
• Carcinoma, Ehrlich Tumor (drug therapy, metabolism)
• Cell Transformation, Neoplastic (drug effects)
• DNA, Neoplasm (biosynthesis)
• Depression, Chemical
• Mice
• Mitosis (drug effects)
• Neoplasm Transplantation
• Thymidine (metabolism)
• Time Factors
• Tritium
• Valinomycin (pharmacology)