Abstract | BACKGROUND AND AIMS: METHODS: Subjects (n = 11) had suffered from heartburn four times or more per week for at least 6 months. Gastric pH and oesophageal pH were measured before, during and after a standard meal ingested over 15 min. Each subject received placebo or 10 mg cisapride orally, 30 min before the beginning of the meal. Meal-stimulated gastric acid secretion was calculated from the amount of HCl required to titrate the homogenized standard meal to pH 2 in vitro and the time required for the pH of the ingested meal to decrease to pH 2 in vivo. Heartburn severity was assessed at 15-min intervals beginning at the end of the meal. Gastric emptying of solids was measured using a [(13)C]- octanoic acid breath test. RESULTS:
Cisapride significantly decreased meal-stimulated gastric acid secretion by 20%, decreased integrated gastric and oesophageal acidity by 50-60% and transiently increased the expiration of (13)CO(2). Cisapride did not significantly alter heartburn severity. CONCLUSIONS: The cisapride-induced decreases in meal-stimulated gastric acid secretion, gastric acidity and oesophageal acidity in subjects with gastro-oesophageal reflux disease can account for its beneficial clinical effects. These results also raise the possibility that gastric KCNQ1 potassium channels are important in meal-stimulated gastric acid secretion and possibly in the pathophysiology of gastro-oesophageal reflux disease.
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Authors | J D Gardner, S Rodriguez-Stanley, M Robinson, P B Miner Jr |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 16
Issue 10
Pg. 1819-29
(Oct 2002)
ISSN: 0269-2813 [Print] England |
PMID | 12269977
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Gastrointestinal Agents
- Serotonin Receptor Agonists
- Cisapride
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Topics |
- Adult
- Cisapride
(pharmacology, therapeutic use)
- Cross-Over Studies
- Female
- Gastric Acid
(metabolism)
- Gastric Acidity Determination
- Gastric Emptying
(drug effects)
- Gastroesophageal Reflux
(drug therapy, physiopathology)
- Gastrointestinal Agents
(pharmacology, therapeutic use)
- Heartburn
(drug therapy, physiopathology)
- Humans
- Hydrogen-Ion Concentration
(drug effects)
- Male
- Middle Aged
- Postprandial Period
- Serotonin Receptor Agonists
(pharmacology, therapeutic use)
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