Successful treatment of lichen planus with low-molecular-weight heparin: a case series of seven patients.

Abstract

BACKGROUND:

Lichen planus (LP) is characterized by features of a cell-mediated attack on the epidermis by activated T lymphocytes. CD4+ lymphocytes have been shown to produce endoglycosidase (heparanase), which allows them to penetrate into the subendothelial basal lamina. Low-molecular-weight heparin (enoxaparin) has been shown to inhibit expression of heparanase.

METHODS:

Seven patients with LP were treated with enoxaparin.

RESULTS:

Five experienced a marked improvement with no side effects.

CONCLUSION:

Enoxaparin may be an effective treatment for patients with lichen planus.

• Authors: H Pacheco, F Kerdel
• Journal: The Journal of dermatological treatment (J Dermatolog Treat) Vol. 12 Issue 2 Pg. 123-6 (Jun 2001) ISSN: 0954-6634 [Print] England
• PMID: 12243672 (Publication Type: Case Reports, Journal Article)

Chemical References

• Enzyme Inhibitors
• Heparin, Low-Molecular-Weight
• heparanase
• Glucuronidase

Topics

• Adult
• Aged
• Aged, 80 and over
• Enzyme Inhibitors (therapeutic use)
• Female
• Glucuronidase (antagonists & inhibitors)
• Heparin, Low-Molecular-Weight (therapeutic use)
• Humans
• Lichen Planus (drug therapy)
• Male
• Middle Aged