Abstract | BACKGROUND: METHODS: RESULTS: Compared to control subjects, the three groups of patients, particularly the IgA GN patients, had higher serum levels of antibodies recognising LDL oxidised with the four different modalities and higher concentrations of cholesterol in circulating immune complexes. None of these were significantly correlated with any demographic, histological or biochemical laboratory finding. In patients with IgAGN, we investigated the possible confounding effects of cardiovascular risk factors ( hypercholesterolemia, hypertension, diabetes and overt atherosclerosis). Although the concentration of cholesterol in circulating immune complexes was significantly higher in patients with cardiovascular risk factors, no significant differences were observed in the level of anti-oxidised- LDL antibodies. This analysis, however, was impossible in FGS and MGN patients because of the high prevalence of hypercholesterolemia in these groups. CONCLUSIONS: These results suggest that IgA GN, MGN and FGS are associated with an enhanced immune response to LDL oxidised with different stimuli mimicking the pro-oxidant environment occurring in vivo, mirrored by the increased levels of specific antibodies, very likely linked to enhanced in vivo LDL oxidation which might participate in glomerular damage and progression.
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Authors | Alessandro Fornasieri, Cristina Perugini, Milfred Seccia, Pietro Napodano, Giuseppe D'Amico, Giorgio Bellomo |
Journal | Journal of nephrology
(J Nephrol)
2002 Jul-Aug
Vol. 15
Issue 4
Pg. 349-57
ISSN: 1121-8428 [Print] Italy |
PMID | 12243363
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- Biomarkers
- Lipoproteins, LDL
- oxidized low density lipoprotein
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Topics |
- Adult
- Aged
- Antibody Specificity
- Autoantibodies
(analysis)
- Biomarkers
(analysis)
- Case-Control Studies
- Cohort Studies
- Enzyme-Linked Immunosorbent Assay
- Female
- Glomerulonephritis, IGA
(diagnosis, immunology)
- Glomerulonephritis, Membranous
(diagnosis, immunology)
- Glomerulosclerosis, Focal Segmental
(diagnosis, immunology)
- Humans
- Linear Models
- Lipoproteins, LDL
(immunology, metabolism)
- Male
- Middle Aged
- Probability
- Reference Values
- Sensitivity and Specificity
- Severity of Illness Index
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