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Failure of radiation therapy for brain involvement in Erdheim Chester disease.

Abstract
A patient with suprasellar and brain stem involvement in Erdheim Chester disease (ECD) underwent magnetic resonance (MR) imaging and proton MR spectroscopy (1H MRS) of the ventral pons before and 1, 4 and 18 months after external whole-brain (24 Gy) radiotherapy. By revealing a decrease of the N-acetyl-aspartate/choline ratio in the pons, 1H MR spectroscopy anticipated lesions growth on MR imaging. In line with the results in four patients reported in the literature, our observation indicates that external radiation therapy is not effective for intracranial involvement in ECD.
AuthorsMario Mascalchi, Patrizia Nencini, Marco Nistri, Cristina Sarti, Riccardo Santoni
JournalJournal of neuro-oncology (J Neurooncol) Vol. 59 Issue 2 Pg. 169-72 (Sep 2002) ISSN: 0167-594X [Print] United States
PMID12241111 (Publication Type: Case Reports, Journal Article)
Topics
  • Brain (pathology)
  • Brain Diseases (complications, diagnosis, radiotherapy)
  • Erdheim-Chester Disease (complications, diagnosis, radiotherapy)
  • Humans
  • Magnetic Resonance Imaging
  • Magnetic Resonance Spectroscopy
  • Male
  • Middle Aged
  • Treatment Outcome

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