Abstract | OBJECTIVE: BACKGROUND: DESIGN/METHODS: Fifteen patients (age range 24-55 years; gender 10 males; 5 females) with recurrent oligos and on AEDs were treated prospectively with CPT-11. Four cohorts of patients defined by CPT-11 dose were treated. Three patients were treated with 400 mg/m2 every 3 weeks, 3 patients 500 mg/m2, 6 patients 600 mg/m2 and 3 patients 700 mg/m2. Neuroradiographic evaluation was performed after every other dose of CPT-11. In patients with stable or responding disease, two further doses of CPT-11 were administered. Alternative or supportive care was offered to patients with disease progression. RESULTS: Toxicity included neutropenia (3 patients; 1 each with Grade III and Grade IV toxicity); thrombocytopenia (2 patients; 1 with Grade IV toxicity); abdominal pain with or without diarrhea (5 patients; 1 with Grade III toxicity) nausea/ vomiting (4 patients). No patient required hospitalization nor did a treatment-related death occur. One patient required a platelet transfusion. Toxicity was a function of CPT-11 dose and the maximum tolerated dose was 600 mg/m2. Cycles (2-12) of CPT-11 were administered (median 4). Response was as follows: partial response (2 patients); stable disease (5 patients); and progressive disease (8 patients). Duration of response ranged from 1.5 to 9 months with a median of 3. In patients with either stable disease or a partial response, response duration was 4.5-9 months (median 6 months). Progression-free survival at 6 months was 33% and 0% at 12 months. Overall survival following initiation of CPT-11 ranged from 2 to 12 months (median 3 months). In patients with either stable or responding disease, median survival was 7 months (range 6-12 months). CONCLUSION: In this small cohort of patients with recurrent low-grade oligos having been treated previously with PCV and on cytochrome P450 enzyme inducing AEDs, CPT-11 has modest palliative efficacy and acceptable toxicity. A dose of 600 mg/m2 every 3 weeks of CPT-11 in patients on AEDs is suggested based on toxicity analysis.
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Authors | Marc C Chamberlain |
Journal | Journal of neuro-oncology
(J Neurooncol)
Vol. 59
Issue 2
Pg. 157-63
(Sep 2002)
ISSN: 0167-594X [Print] United States |
PMID | 12241109
(Publication Type: Clinical Trial, Clinical Trial, Phase I, Journal Article)
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Chemical References |
- Anticonvulsants
- Antineoplastic Agents, Phytogenic
- Irinotecan
- Camptothecin
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Topics |
- Adult
- Anticonvulsants
(therapeutic use)
- Antineoplastic Agents, Phytogenic
(adverse effects, therapeutic use)
- Brain Neoplasms
(drug therapy, mortality)
- Camptothecin
(adverse effects, analogs & derivatives, therapeutic use)
- Disease-Free Survival
- Female
- Gastrointestinal Diseases
(chemically induced)
- Humans
- Irinotecan
- Male
- Maximum Tolerated Dose
- Middle Aged
- Neoplasm Recurrence, Local
(drug therapy)
- Neutropenia
(chemically induced)
- Oligodendroglioma
(drug therapy, mortality)
- Polypharmacy
- Prospective Studies
- Salvage Therapy
(adverse effects)
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