HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Reactivity of peripheral blood lymphocytes in children with pituitary dwarfism treated with human growth hormone (author's transl)].

Abstract
The study has aimed at investigating the blastic transformation of peripheral blood lymphocytes in patients with pituitary dwarfism before, during and after the treatment with human growth hormone. The reactivity of lymphocytes in vitro was studied in cultures stimulated with phytohemagglutinin-M of the Difco Company (PHA), in cultures stimulated with human growth hormone (HGH), and in cultures non-stimulated in vitro. The investigations were carried out in 34 patients with pituitary dwarfism at the age of 7 to 19 years. The control group was made up of 16 healthy children, 8 to 15 years old who had never been administered HGH. The patients were divided into groups according to the circumstance whether it was the first or the subsequent contact with HGH, and according to the periods at which the blood samples were collected during after therapy. It was found that the capability of lymphocytes to blastic transformation after stimulation with a specific stimulus (HGH) in patients with pituitary dwarfism in comparison with the reaction of healthy children is reduced (Fig. 2). The ability of the transformation of lymphocytes in this case shows selectivity towards the stimulus because the inhibiting of the response was noted only after the stimulation with HGH, but not after stimulation with PHA. During the treatment with HGH, allergization of the body appears; this is evidenced by the increase in the percentage of blastic cells in autotransformation (Fig. 1).
AuthorsA Kunicka, I Lenartowska, M Sielicka
JournalProblemy medycyny wieku rozwojowego (Probl Med Wieku Rozwoj) Vol. 5 Pg. 155-60 ( 1975) ISSN: 0303-2264 [Print] Poland
Vernacular TitleReaktywność limfocytów krwi obwodowej u dzieci z karłowatościa przysadkowa, leczonych ludzkim hormonem wzrostu
PMID1223865 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Growth Hormone
Topics
  • Adolescent
  • Adult
  • Child
  • Depression, Chemical
  • Dwarfism, Pituitary (drug therapy, immunology)
  • Female
  • Growth Hormone (immunology, pharmacology, therapeutic use)
  • Humans
  • Lymphocyte Activation
  • Lymphocytes (immunology)
  • Male

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: