Abstract |
To investigate the proliferation of neural stem cells (NSC) in epileptic brain, spaciotemporal expression of immunoreactive bromodeoxyuridine ( BrdU) was examined in kindling development of rat. Amygdaloid kindling in partial seizure (PS) was effective in proliferation of NSC detected with BrdU-labeling in subventricular zone (SVZ), but not in dentate gyrus (DG). In SVZ, however, the BrdU-labeling cells decreased at stage generalized seizure (GS). These facts indicate that proliferation of NSC increased with PS and decreased with more severe seizures of GS in SVZ, that such a proliferation did not occur in DG with PS or GS. Thus, the proliferation of NSC was spacially and temporally different between brain regions depending on different kindling stages.
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Authors | K Sato, M Iwai, I Nagano, M Shoji, K Abe |
Journal | Neurological research
(Neurol Res)
Vol. 24
Issue 6
Pg. 593-6
(Sep 2002)
ISSN: 0161-6412 [Print] England |
PMID | 12238626
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Amygdala
(metabolism, pathology)
- Animals
- Bromodeoxyuridine
(immunology, metabolism)
- Disease Models, Animal
- Electric Stimulation
(methods)
- Hippocampus
(metabolism, pathology)
- Immunohistochemistry
- In Situ Nick-End Labeling
- Kindling, Neurologic
(metabolism)
- Lateral Ventricles
(metabolism, pathology)
- Male
- Matched-Pair Analysis
- Neuronal Plasticity
- Rats
- Rats, Sprague-Dawley
- Seizures
(chemically induced, metabolism, pathology)
- Stem Cells
(cytology, metabolism)
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