Abstract | OBJECTIVE: METHODS: Pigs were on normal chow (control group), on a cholesterol-rich diet for 37 weeks (hypercholesterolemic group) or on a cholesterol-rich diet followed by normal chow for 26 weeks ( cholesterol withdrawal group). Endothelial function was assessed with quantitative angiography after intracoronary infusion of acetylcholine, plaque load with intra-coronary ultrasound and plaque composition with image analysis of cross-sections. The effect of porcine serum on coronary smooth muscle cell (SMC) function was studied in vitro. RESULTS: CONCLUSIONS:
Cholesterol lowering induced coronary plaque stabilization as evidenced by a decrease in lipids, ox-LDL, macrophages, apoptosis and cell proliferation, and an increase in differentiated SMC and collagen. Increased migration and decreased apoptosis of SMC may contribute to the disappearance of the a-cellular core after lipid lowering.
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Authors | Peter Verhamme, Rozenn Quarck, Hiroyuki Hao, Michiel Knaapen, Steven Dymarkowski, Hilde Bernar, Johan Van Cleemput, Stefan Janssens, Jozef Vermylen, Giulio Gabbiani, Mark Kockx, Paul Holvoet |
Journal | Cardiovascular research
(Cardiovasc Res)
Vol. 56
Issue 1
Pg. 135-44
(Oct 2002)
ISSN: 0008-6363 [Print] England |
PMID | 12237174
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholesterol, Dietary
- Lipoproteins, LDL
- oxidized low density lipoprotein
- Collagen
- C-Reactive Protein
- Acetylcholine
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Topics |
- Acetylcholine
- Animals
- Apoptosis
- C-Reactive Protein
(metabolism)
- Cell Division
- Cell Movement
- Cells, Cultured
- Cholesterol, Dietary
- Collagen
(metabolism)
- Coronary Disease
(diagnostic imaging, diet therapy, metabolism)
- Coronary Vessels
(diagnostic imaging)
- Endothelium, Vascular
(metabolism)
- Extracellular Matrix
(metabolism)
- Hypercholesterolemia
(diagnostic imaging, diet therapy, metabolism)
- Lipoproteins, LDL
(blood)
- Models, Animal
- Muscle, Smooth, Vascular
(pathology)
- Swine, Miniature
- Ultrasonography
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