Abstract |
The aim of the present study was to find out whether the metabotropic receptor 1 ( mGluR1) and group II mGluRs, localized in the striatum, are involved in antiparkinsonian-like effects in rats. Haloperidol (1 mg/kg ip) induced parkinsonian-like muscle rigidity, measured as an increased resistance of a rat's hind foot to passive flexion and extension at the ankle joint. (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA; 0.5-15 microg/0.5 microl), a potent and selective mGluR1 antagonist, or (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC; 7.5-15 microg/0.5 microl), a selective group II agonist, was injected bilaterally into the striatum of haloperidol-treated animals. AIDA in doses of 7.5-15 microg/0.5 microl diminished the haloperidol-induced muscle rigidity. In contrast, 2R,4R-APDC injections were ineffective. The present results may suggest that the blockade of striatal mGluR1, but not the stimulation of group II mGluRs, may ameliorate parkinsonian muscle rigidity.
|
Authors | Krystyna Ossowska, Jolanta Konieczny, Andrzej Pilc, Stanislaw Wolfarth |
Journal | Brain research
(Brain Res)
Vol. 950
Issue 1-2
Pg. 88-94
(Sep 20 2002)
ISSN: 0006-8993 [Print] Netherlands |
PMID | 12231232
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antiparkinson Agents
- Receptors, Metabotropic Glutamate
- metabotropic glutamate receptor 2
- metabotropic glutamate receptor type 1
|
Topics |
- Animals
- Antiparkinson Agents
(administration & dosage)
- Corpus Striatum
(drug effects, physiology)
- Drug Delivery Systems
(methods)
- Male
- Parkinsonian Disorders
(chemically induced, drug therapy, physiopathology)
- Rats
- Rats, Wistar
- Receptors, Metabotropic Glutamate
(agonists, antagonists & inhibitors, physiology)
|