Progestins and endometrial cancer.

Abstract

Premenopausal women--especially young women--with endometrial cancer stage I may be treated successfully with progestins alone as primary therapy to preserve their child-bearing potential. There is some indication that progestins could be used in neoadjuvant fashion. Individualization of adjuvant treatment with radiation or progestins and in combination seems possible. Progestins have an established place in the palliative treatment of women with advanced cancer. In addition, progestins can be used in advanced and/or recurrent endometrial cancer in combination with chemotherapy and tamoxifen.

• Authors: A E Schindler
• Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (Gynecol Endocrinol) Vol. 15 Suppl 6 Pg. 29-36 (Dec 2001) ISSN: 0951-3590 [Print] England
• PMID: 12227884 (Publication Type: Journal Article, Review)

Chemical References

• Estrogen Antagonists
• Progestins
• Tamoxifen

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Combined Modality Therapy
• Endometrial Neoplasms (drug therapy, pathology, radiotherapy)
• Estrogen Antagonists (therapeutic use)
• Female
• Humans
• Middle Aged
• Neoplasm Recurrence, Local (drug therapy)
• Premenopause
• Progestins (administration & dosage, therapeutic use)
• Risk Factors
• Tamoxifen (therapeutic use)