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[HLA class I antigen expression correlates with histological cell type in uveal melanoma].

AbstractPURPOSE:
The prognosis of uveal melanoma is correlated with its histologic cell type. The epithelioid cell type is associated with a higher metastatic rate than the spindle cell type. The Human Leucocyte Antigen Class I (HLA-I) expression of the melanoma also correlates with the prognosis. In this study, we analyzed HLA-I antigen expression of uveal melanomas to determine whether a relationship exist between antigenic expression and melanoma cell type.
METHODS:
Formalin-fixed, paraffin-embedded spindle cell type (n = 11) and epithelioid cell type (n = 11) uveal melanomas were immunostained with the HC10 antibody (1:80) for HLA-I antigen expression with appropriate positive and negative controls. Sections were assessed semiquantitatively according to the percentage of stained cells.
RESULTS:
Among the spindle cell type melanomas, 2 out of 11 (18%) stained with HC10 antibodies. The staining intensity was less than 25% of the cells in these two melanomas. Among the epithelioid cell type melanomas, 9 out of 11 (82%) stained with HC10. The staining intensity was more than 25% of the cells in 5 of these 9 melanomas.
CONCLUSIONS:
It is unknown why spindle and epithelioid cell type uveal melanomas have different prognoses. Human uveal melanoma cell lines with low HLA-I expression are susceptible to NK cell-mediated lysis in vitro and in murine studies. The prognostically more favorable spindle cell type melanoma expresses less HLA-I than the epithelioid cell type melanoma. These results stress the role of NK cells in the rejection of uveal melanoma.
AuthorsS Dithmar, J Crowder, M J Jager, N Vigniswaran, H E Grossniklaus
JournalDer Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft (Ophthalmologe) Vol. 99 Issue 8 Pg. 625-8 (Aug 2002) ISSN: 0941-293X [Print] Germany
Vernacular TitleHLA-I-Antigenexpression korreliert mit dem histologischen Zelltyp uvealer Melanome.
PMID12227276 (Publication Type: English Abstract, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Histocompatibility Antigens Class I
Topics
  • Histocompatibility Antigens Class I (analysis)
  • Humans
  • Immunoenzyme Techniques
  • Melanoma (classification, pathology)
  • Prognosis
  • Uvea (pathology)
  • Uveal Neoplasms (classification, pathology)

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