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Expression of cytolytic lymphocyte-associated antigens in pulmonary lymphomatoid granulomatosis.

Abstract
Paraffin-embedded lung wedge biopsy specimens from 14 patients with pulmonary lymphomatoid granulomatosis (LYG) were analyzed using immunoperoxidase stains specific for T cell- and natural killer cell-associated antigens. Nine cases had a minor population of CD20+ large B-cells (B-cell LYG) amidst a background of CD3- and betaF1-immunoreactive T cells. In 8 of the 9 B-cell LYG cases, the majority of the background T lymphocytes had a cytotoxic phenotype as defined by the expression of CD8 and the cytotoxic granule proteins TIA-1 (granule membrane protein 17) and granzyme B. Five cases lacked CD20+ large cells and, instead, showed predominantly CD3+ and betaF1 + T cells (T-cell LYG). Whereas the small, medium, and large atypical lymphocytes were all positive for CD3 and betaF1 in the T-cell LYG cases, immunoreactivity for CD8, TIA-1, and granzyme B was limited to the small lymphocytes, with a distribution indistinguishable from that seen in B-cell LYG. These findings indicate that LYG is composed of a heterogeneous group of lymphoproliferative disorders that share, as unifying features, a relative paucity of neoplastic cells and a prominent reactive infiltrate rich in cytolytic lymphocytes.
AuthorsWilliam G Morice, Paul J Kurtin, Jeffrey L Myers
JournalAmerican journal of clinical pathology (Am J Clin Pathol) Vol. 118 Issue 3 Pg. 391-8 (Sep 2002) ISSN: 0002-9173 [Print] England
PMID12219781 (Publication Type: Journal Article)
Chemical References
  • Antigens, CD
  • Antigens, Surface
  • Epstein-Barr virus encoded RNA 1
  • Epstein-Barr virus encoded RNA 2
  • RNA, Viral
Topics
  • Antigens, CD (analysis)
  • Antigens, Surface (immunology)
  • B-Lymphocytes (immunology, pathology, virology)
  • Epstein-Barr Virus Infections (complications, pathology)
  • Herpesvirus 4, Human (isolation & purification, pathogenicity)
  • Humans
  • Immunoenzyme Techniques
  • Immunophenotyping
  • In Situ Hybridization
  • Killer Cells, Natural (immunology, pathology)
  • Lung Diseases (immunology, pathology, virology)
  • Lymphomatoid Granulomatosis (immunology, pathology, virology)
  • RNA, Viral (analysis)
  • Survival Rate
  • T-Lymphocytes, Cytotoxic (immunology, pathology, virology)

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