Abstract |
Paraffin-embedded lung wedge biopsy specimens from 14 patients with pulmonary lymphomatoid granulomatosis (LYG) were analyzed using immunoperoxidase stains specific for T cell- and natural killer cell-associated antigens. Nine cases had a minor population of CD20+ large B-cells (B-cell LYG) amidst a background of CD3- and betaF1-immunoreactive T cells. In 8 of the 9 B-cell LYG cases, the majority of the background T lymphocytes had a cytotoxic phenotype as defined by the expression of CD8 and the cytotoxic granule proteins TIA-1 (granule membrane protein 17) and granzyme B. Five cases lacked CD20+ large cells and, instead, showed predominantly CD3+ and betaF1 + T cells (T-cell LYG). Whereas the small, medium, and large atypical lymphocytes were all positive for CD3 and betaF1 in the T-cell LYG cases, immunoreactivity for CD8, TIA-1, and granzyme B was limited to the small lymphocytes, with a distribution indistinguishable from that seen in B-cell LYG. These findings indicate that LYG is composed of a heterogeneous group of lymphoproliferative disorders that share, as unifying features, a relative paucity of neoplastic cells and a prominent reactive infiltrate rich in cytolytic lymphocytes.
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Authors | William G Morice, Paul J Kurtin, Jeffrey L Myers |
Journal | American journal of clinical pathology
(Am J Clin Pathol)
Vol. 118
Issue 3
Pg. 391-8
(Sep 2002)
ISSN: 0002-9173 [Print] England |
PMID | 12219781
(Publication Type: Journal Article)
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Chemical References |
- Antigens, CD
- Antigens, Surface
- Epstein-Barr virus encoded RNA 1
- Epstein-Barr virus encoded RNA 2
- RNA, Viral
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Topics |
- Antigens, CD
(analysis)
- Antigens, Surface
(immunology)
- B-Lymphocytes
(immunology, pathology, virology)
- Epstein-Barr Virus Infections
(complications, pathology)
- Herpesvirus 4, Human
(isolation & purification, pathogenicity)
- Humans
- Immunoenzyme Techniques
- Immunophenotyping
- In Situ Hybridization
- Killer Cells, Natural
(immunology, pathology)
- Lung Diseases
(immunology, pathology, virology)
- Lymphomatoid Granulomatosis
(immunology, pathology, virology)
- RNA, Viral
(analysis)
- Survival Rate
- T-Lymphocytes, Cytotoxic
(immunology, pathology, virology)
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