[Dolasetron reduces pain on injection of propofol].

Abstract

OBJECTIVE:

Pain on injection is a well known side-effect of propofol. The present study was designed to assess the efficacy of dolasetron, a 5-HT 3 -antagonist, in prophylaxis of pain on injection of propofol compared with lidocaine and placebo.

METHODS:

Prospective, randomised, double-blinded study including 150 patients randomly assigned to one of three groups: Group A received 12.5 mg dolasetron, group B 40 mg lidocaine and group C saline 0.9 % as placebo. After occluding the venous drainage the test medication was given. The occlusion was released after 1 min and 2.0 mg/kg Propofol was administered over a period of 30 sec. The patients were asked whether they felt any pain during the administration. Pain on injection was judged by using a four-point scale.

RESULTS:

Incidence of pain on injection as well as the severity of pain was significantly reduced by lidocaine (62 % pain free) compared with placebo (28 %). Severity, but not incidence of pain on injection was significantly reduced by dolasetron (50 %) compared with placebo. There was no significant difference between dolasetron and lidocaine.

CONCLUSION:

Dolasetron and lidocaine were effective in preventing pain of injection secondary to propofol.

• Authors: S N Piper, K D Röhm, M Papsdorf, W H Maleck, P Mattinger, J Boldt
• Journal: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS (Anasthesiol Intensivmed Notfallmed Schmerzther) Vol. 37 Issue 9 Pg. 528-31 (Sep 2002) ISSN: 0939-2661 [Print] Germany
• Vernacular Title: Dolasetron verringert den Propofol-induzierten Injektionsschmerz.
• PMID: 12215937 (Publication Type: English Abstract, Retraction of Publication)