Abstract | OBJECTIVE: STUDY DESIGN: Open randomised multicentre study. Women were treated with multiple insulin injections aiming at normoglycaemia. Blood glucose was determined six times daily, HbA(1c) every 4 weeks. Diurnal profiles of blood glucose were analysed at gestational week 14 and during the study period at weeks 21, 28 and 34. PARTICIPANTS: RESULTS:
Blood glucose was significantly lower (P<0.01) after breakfast in the lispro group, while there were no significant group differences in glycemic control during the rest of the day. Severe hypoglycaemia occurred in two patients in the regular group but biochemical hypoglycaemia ( blood glucose <3.0 mmol/l) was more frequent in the lispro than in the regular group (5.5 vs. 3.9%, respectively). HbA(1c) values at inclusion were 6.5 and 6.6% in the lispro and regular group respectively. HbA(1c) values declined during the study period and were similar in both groups. There was no perinatal mortality. Complications during pregnancy, route of delivery and foetal outcome did not differ between the groups. Retinopathy progressed in both groups, one patient in the regular group developed proliferative retinopathy. CONCLUSION:
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Authors | B Persson, M-L Swahn, R Hjertberg, U Hanson, E Nord, E Nordlander, L-O Hansson |
Journal | Diabetes research and clinical practice
(Diabetes Res Clin Pract)
Vol. 58
Issue 2
Pg. 115-21
(Nov 2002)
ISSN: 0168-8227 [Print] Ireland |
PMID | 12213353
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Blood Glucose
- Glycated Hemoglobin A
- Hypoglycemic Agents
- Insulin
- Insulin Lispro
- Insulin, Regular, Pork
- insulin, neutral
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Topics |
- Adult
- Blood Glucose
(drug effects, metabolism)
- Diabetes Mellitus, Type 1
(drug therapy)
- Diabetic Angiopathies
(epidemiology)
- Diabetic Retinopathy
(epidemiology)
- Drug Administration Schedule
- Female
- Glycated Hemoglobin
(metabolism)
- Humans
- Hypoglycemic Agents
(administration & dosage, therapeutic use)
- Infant, Newborn
- Insulin
(administration & dosage, analogs & derivatives, therapeutic use)
- Insulin Lispro
- Insulin, Regular, Pork
- Parity
- Pregnancy
- Pregnancy Outcome
- Pregnancy in Diabetics
(drug therapy)
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