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Impact of genomic instability in risk assessment and chemoprevention of oral premalignancies.

Abstract
Head-and-neck cancer is a disfiguring disease with increasing incidence rates even in young people, whose exposure to known risk factors is limited. This emphasizes the importance of early identification, on an individual basis, of precursor lesions that will develop into carcinomas. The clinical value of identifying individuals at high risk of oral cancer is emphasized by the fact that these patients are likely to benefit from available chemopreventive measures, largely without adverse effects.
AuthorsAlbrecht Reith, Jon Sudbø
JournalInternational journal of cancer (Int J Cancer) Vol. 101 Issue 3 Pg. 205-9 (Sep 20 2002) ISSN: 0020-7136 [Print] United States
PMID12209969 (Publication Type: Journal Article, Review)
CopyrightCopyright 2002 Wiley-Liss, Inc.
Chemical References
  • Antineoplastic Agents
  • Biomarkers, Tumor
Topics
  • Antineoplastic Agents (therapeutic use)
  • Biomarkers, Tumor (metabolism)
  • Carcinoma, Squamous Cell (genetics, pathology, prevention & control)
  • Chemoprevention
  • Chromosome Aberrations
  • Clinical Trials as Topic
  • Genetic Predisposition to Disease
  • Humans
  • Mouth Neoplasms (genetics, pathology, prevention & control)
  • Ploidies
  • Prognosis
  • Risk Assessment

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