No association between the serotonergic polymorphisms and incidence of nausea induced by fluvoxamine treatment.

Abstract

We investigated the association between serotonergic polymorphisms and incidence of nausea, which is the most frequent side-effect of selective serotonin reuptake inhibiters (SSRIs), in 66 patients treated with fluvoxamine in a protocolized-dosing method. We focused on three polymorphisms of serotonin (5-HT) neuronal systems such as 5-HT transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR), a variable number of tandem repeat (VNTR) polymorphism in the second intron of the 5-HTT gene (STin2) and tryptophan hydroxylase (TPH) gene polymorphism in intron 7 (TPH-A218C), which have been reported to possess positive association with treatment response to SSRIs. In addition to this, the relationship between development of nausea and treatment response was also analyzed. Results suggested that these three polymorphisms did not affect the development of fluvoxamine-induced nausea, and that incidence of nausea was not a phenomenon that predicts the treatment response to fluvoxamine.

• Authors: Hitoshi Takahashi, Keizo Yoshida, Kenich Ito, Kazuhiro Sato, Mitsuhiro Kamata, Hisashi Higuchi, Tetsuo Shimizu, Kunihiko Ito, Kazuyuki Inoue, Takehiko Tezuka, Toshio Suzuki, Tadashi Ohkubo, Kazunobu Sugawara
• Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology (Eur Neuropsychopharmacol) Vol. 12 Issue 5 Pg. 477-81 (Oct 2002) ISSN: 0924-977X [Print] Netherlands
• PMID: 12208565 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Antidepressive Agents, Second-Generation
• Carrier Proteins
• Membrane Glycoproteins
• Membrane Transport Proteins
• Nerve Tissue Proteins
• SLC6A4 protein, human
• Serotonin Plasma Membrane Transport Proteins
• Tryptophan Hydroxylase
• Fluvoxamine

Topics

• Adult
• Aged
• Antidepressive Agents, Second-Generation (adverse effects, blood, therapeutic use)
• Carrier Proteins (genetics)
• Chi-Square Distribution
• Depressive Disorder, Major (drug therapy, genetics)
• Female
• Fluvoxamine (adverse effects, blood, therapeutic use)
• Gene Frequency
• Genotype
• Humans
• Introns (genetics)
• Linkage Disequilibrium
• Male
• Membrane Glycoproteins (genetics)
• Membrane Transport Proteins
• Middle Aged
• Minisatellite Repeats (genetics)
• Nausea (chemically induced)
• Nerve Tissue Proteins
• Polymorphism, Genetic
• Serotonin Plasma Membrane Transport Proteins
• Tryptophan Hydroxylase (genetics)