Salivary duct carcinoma: cytokeratin 14 as a marker of in-situ intraductal growth.

Abstract

AIMS:

The aim of this study was to determine the immunoprofile of salivary duct carcinoma and to differentiate intraductal growth from invasive growth.

METHODS AND RESULTS:

We applied a panel of antibodies (cytokeratins 7, 8, 13, 14, 19, vimentin and alpha-smooth muscle actin) in five cases of salivary duct carcinoma. This panel is currently used for identification of different components of salivary gland tumours in our laboratory. All tumour cells were positive for cytokeratins 7 and 8. Few neoplastic structures expressed cytokeratin 14 in cells surrounding tumour islands.

CONCLUSION:

The finding of cytokeratin 14 was important to confirm the in-situ intraductal growth, which probably characterizes this low-grade neoplasm.

• Authors: V C de Araújo, L P Kowalski, F Soares, N S de Araújo, S V L Loducca, A P V Sobral
• Journal: Histopathology (Histopathology) Vol. 41 Issue 3 Pg. 244-9 (Sep 2002) ISSN: 0309-0167 [Print] England
• PMID: 12207786 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Keratins

Topics

• Adenocarcinoma (metabolism, pathology)
• Aged
• Biomarkers, Tumor (metabolism)
• Female
• Humans
• Immunohistochemistry
• Keratins (metabolism)
• Male
• Middle Aged
• Parotid Neoplasms (metabolism, pathology)