Iodized oil as a complement to iodized salt in schoolchildren in endemic goiter in Romania.

Abstract

OBJECTIVE:

To evaluate the long-term efficacy and possible side effects of low doses of iodized oil on iodine nutrition and thyroid function in endemic goiter in Romania.

METHODS:

Random selection of 214 schoolchildren aged 6-14 years. Serial measurements of urinary iodine, thyroid volume with ultrasound, serum concentrations of thyrotropin, free thyroxine, thyroglobulin and thyroid autoantibodies before and up to 2 years after the oral administration of 200 mg iodine in iodized oil.

RESULTS:

Urinary iodine concentrations indicated a moderate iodine deficiency before therapy, sharply increased soon after therapy and slowly decreased thereafter but remained within the normal range up to more than 1 year after therapy. The prevalence of goiter was 29% before the administration of iodized oil and 9% 1 year later. Thyroid function tests and autoantibodies were normal before and up to 2 years after therapy.

CONCLUSION:

A single dose of 200 mg iodine from oral Lipiodol appears adequate and safe for correcting moderate iodine deficiency in children.

• Authors: M Simescu, M Varciu, E Nicolaescu, D Gnat, J Podoba, M Mihaescu, F Delange
• Journal: Hormone research (Horm Res) Vol. 58 Issue 2 Pg. 78-82 ( 2002) ISSN: 0301-0163 [Print] Switzerland
• PMID: 12207166 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2002 S. Karger AG, Basel

Chemical References

• Sodium Chloride, Dietary
• Iodized Oil
• Thyrotropin
• Iodine
• Iodide Peroxidase
• Thyroxine

Topics

• Adolescent
• Child
• Female
• Goiter, Endemic (diet therapy)
• Humans
• Iodide Peroxidase (blood, immunology)
• Iodine (urine)
• Iodized Oil (administration & dosage, adverse effects, therapeutic use)
• Male
• Romania
• Sodium Chloride, Dietary
• Thyroid Function Tests
• Thyrotropin (blood)
• Thyroxine (blood)