Abstract | BACKGROUND: We previously showed that serum promatrix metalloproteinase-2 (proMMP-2) concentrations were increased in cirrhotic patients, reflecting the increase in liver proMMP-2 concentrations. We examined whether the increased proMMP-2 concentration reflects the biological matrix metalloproteinase-2 (MMP-2) activity. METHODS: We measured serum concentrations of active MMP-2 and proMMP-2, and calculated the active MMP-2/proMMP-2 ratio as an index of the proMMP-2 activation rate in chronic viral liver disease. RESULTS: CONCLUSION:
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Authors | Yoshikazu Murawaki, Yujiro Ikuta, Masahiko Koda, Kinya Okamoto, Kenichi Mimura |
Journal | Clinica chimica acta; international journal of clinical chemistry
(Clin Chim Acta)
Vol. 324
Issue 1-2
Pg. 99-103
(Oct 2002)
ISSN: 0009-8981 [Print] Netherlands |
PMID | 12204430
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2002 Elsevier Science B.V. |
Chemical References |
- Biomarkers
- Enzyme Precursors
- Gelatinases
- Metalloendopeptidases
- progelatinase
- Matrix Metalloproteinase 2
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Topics |
- Adult
- Biomarkers
(blood)
- Chronic Disease
- Enzyme Activation
- Enzyme Precursors
(blood, metabolism)
- Female
- Gelatinases
(blood, metabolism)
- Humans
- Kinetics
- Liver Diseases
(blood, enzymology, virology)
- Male
- Matrix Metalloproteinase 2
(blood, metabolism)
- Metalloendopeptidases
(blood, metabolism)
- Middle Aged
- Virus Diseases
(blood, enzymology)
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