Abstract | BACKGROUND: METHODS: In this prospective, double-blind, parallel-group study, patients with primary hypercholesterolemia were randomized to treatment with cerivastatin, 0.3 mg (n = 21) or lovastatin, 20 mg (n = 22), for 8 weeks. The primary efficacy variable was percentage change of low-density lipoprotein ( LDL) cholesterol from baseline. The secondary efficacy variables were percentage change of total cholesterol, triglycerides and high-density lipoprotein ( HDL) cholesterol. RESULTS.:Both cerivastatin and lovastatin effectively reduced LDL cholesterol (-33.2% vs. -29.3%, p = 0.63), total cholesterol (-25% vs. -20%, p = 0.10), and triglycerides (-21% vs. -14%,p = 0.27) (all p < 0.0001 for comparison with baseline), and slight increased HDL cholesterol (+2% vs. +8%, p = 0.008) over the 8-week treatment period. The LDL cholesterol responsive rates according to the recommendations from the National Cholesterol Educational Panel (NCEP) were 43% and 32% for cerivastatin and lovastatin, respectively. The adverse event profiles of cerivastatin and lovastatin were similar. CONCLUSIONS:
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Authors | Wen-Chung Yu, Chen-Huan Chen, Husan-Ming Tsao, Yu-An Ding |
Journal | Zhonghua yi xue za zhi = Chinese medical journal; Free China ed
(Zhonghua Yi Xue Za Zhi (Taipei))
Vol. 65
Issue 6
Pg. 260-7
(Jun 2002)
ISSN: 0578-1337 [Print] China (Republic : 1949- ) |
PMID | 12201566
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholesterol, HDL
- Cholesterol, LDL
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Pyridines
- Triglycerides
- Lovastatin
- cerivastatin
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Topics |
- Adult
- Aged
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Double-Blind Method
- Female
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(therapeutic use)
- Hypercholesterolemia
(blood, drug therapy)
- Lovastatin
(adverse effects, therapeutic use)
- Male
- Middle Aged
- Prospective Studies
- Pyridines
(adverse effects, therapeutic use)
- Triglycerides
(blood)
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