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A randomized, double-blind comparison of cerivastatin and lovastatin for treatment of primary hypercholesterolemia.

AbstractBACKGROUND:
The efficacy and safety of the new statin, cerivastatin, in the Chinese patients with primary hypercholesterolemia remains to be determined.
METHODS:
In this prospective, double-blind, parallel-group study, patients with primary hypercholesterolemia were randomized to treatment with cerivastatin, 0.3 mg (n = 21) or lovastatin, 20 mg (n = 22), for 8 weeks. The primary efficacy variable was percentage change of low-density lipoprotein (LDL) cholesterol from baseline. The secondary efficacy variables were percentage change of total cholesterol, triglycerides and high-density lipoprotein (HDL) cholesterol. RESULTS.:Both cerivastatin and lovastatin effectively reduced LDL cholesterol (-33.2% vs. -29.3%, p = 0.63), total cholesterol (-25% vs. -20%, p = 0.10), and triglycerides (-21% vs. -14%,p = 0.27) (all p < 0.0001 for comparison with baseline), and slight increased HDL cholesterol (+2% vs. +8%, p = 0.008) over the 8-week treatment period. The LDL cholesterol responsive rates according to the recommendations from the National Cholesterol Educational Panel (NCEP) were 43% and 32% for cerivastatin and lovastatin, respectively. The adverse event profiles of cerivastatin and lovastatin were similar.
CONCLUSIONS:
Cerivastatin 0.3 mg once daily is as effective and safe as lovastatin 20 mg once daily in lowering LDL and total cholesterol in Chinese patients with primary hypercholesterolemia.
AuthorsWen-Chung Yu, Chen-Huan Chen, Husan-Ming Tsao, Yu-An Ding
JournalZhonghua yi xue za zhi = Chinese medical journal; Free China ed (Zhonghua Yi Xue Za Zhi (Taipei)) Vol. 65 Issue 6 Pg. 260-7 (Jun 2002) ISSN: 0578-1337 [Print] China (Republic : 1949- )
PMID12201566 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Pyridines
  • Triglycerides
  • Lovastatin
  • cerivastatin
Topics
  • Adult
  • Aged
  • Cholesterol, HDL (blood)
  • Cholesterol, LDL (blood)
  • Double-Blind Method
  • Female
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use)
  • Hypercholesterolemia (blood, drug therapy)
  • Lovastatin (adverse effects, therapeutic use)
  • Male
  • Middle Aged
  • Prospective Studies
  • Pyridines (adverse effects, therapeutic use)
  • Triglycerides (blood)

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