Abstract | BACKGROUND: MATERIAL AND METHOD: A systematic review of randomized clinical trials comparing megestrol acetate with placebo in cancer patients was performed. The outcome measure used was weight gain expressed as the difference in weight at the outset compared with that at the end of treatment. Trials analyzed were those that allowed for this calculation, or those whose authors provided information for the above calculation. RESULTS: Patients treated with placebo had an average weight loss of 1.090 kg (CI 95%, 1.620 to 0.561), whereas patients treated with megestrol acetate gained an average 0.423 kg (CI 95%, 0.078-0.769). A weight gain of 0.448 kg (CI 95%, 0.021-0.874) was observed with acetate megestrol doses # 240 mg. No statistically significant effect was observed when using higher doses: 0.358 kg (CI 95%, 0.135-0.85). CONCLUSIONS:
|
Authors | Vicente Ruiz-García, Oscar Juan, Santiago Pérez Hoyos, Rosana Peiró, Nieves Ramón, M Angeles Rosero, Miguel Angel García |
Journal | Medicina clinica
(Med Clin (Barc))
Vol. 119
Issue 5
Pg. 166-70
(Jul 06 2002)
ISSN: 0025-7753 [Print] Spain |
Vernacular Title | Acetato de megestrol: una revisión sistemática de su utilidad clínica para la ganancia de peso en los enfermos con neoplasia y caquexia. |
PMID | 12200017
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review, Systematic Review)
|
Chemical References |
|
Topics |
- Cachexia
(drug therapy, etiology)
- Humans
- Megestrol Acetate
(pharmacology, therapeutic use)
- Neoplasms
(complications)
- Randomized Controlled Trials as Topic
- Weight Gain
(drug effects)
|