HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Feline thyroid adenomas are in part associated with mutations in the G(s alpha) gene and not with polymorphisms found in the thyrotropin receptor.

Abstract
The etiopathogenesis of feline thyrotoxicosis is unknown. The transmembrane part (gene codons 480-640) of the thyrotropin receptor (TSHR) gene of hyperthyroid cats has already been investigated for the presence of stimulating mutations. No mutations were found in this part of the TSHR gene. We have investigated the TSHR gene codons 66-530 for gene mutations in 10 hyperthyroid cats and in 1 euthyroid cat. This part of the TSHR gene encodes the transmembrane part as well as most of the extracellular part of the receptor. The G(s alpha) gene of these cats was also sequenced and subjected to mutational analysis. Although our study revealed a polymorphism in the TSHR gene, no association was found with tumor formation. In 4 of 10 cats with hyperthyroidism a G(s alpha) gene mutation was found. This work suggests that mutations in the extracellular or transmembrane part of the TSHR gene are not likely the cause of feline hyperthyroidism. Mutations in the G(s alpha) gene, however, may play a role in the etiopathogenesis of this disease.
AuthorsMarijke E Peeters, Elpetra P M Timmermans-Sprang, Jan A Mol
JournalThyroid : official journal of the American Thyroid Association (Thyroid) Vol. 12 Issue 7 Pg. 571-5 (Jul 2002) ISSN: 1050-7256 [Print] United States
PMID12193300 (Publication Type: Journal Article)
Chemical References
  • Codon
  • Receptors, Thyrotropin
  • GTP-Binding Protein alpha Subunits, Gs
Topics
  • Adenoma (genetics)
  • Amino Acid Sequence (genetics)
  • Animals
  • Base Sequence (genetics)
  • Cats
  • Codon (genetics)
  • DNA Mutational Analysis
  • GTP-Binding Protein alpha Subunits, Gs (genetics)
  • Hyperthyroidism (genetics)
  • Molecular Sequence Data
  • Polymorphism, Genetic (physiology)
  • Protein Structure, Tertiary (genetics)
  • Receptors, Thyrotropin (chemistry, genetics)
  • Reference Values
  • Thyroid Neoplasms (genetics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: