[Morphological and biochemical features of cerebral beta-amyloidosis in long-livers].

Abstract

This is the first assessment of the pathogenetic values of some environmental factors in the occurrence and progression of cerebral beta-amyloidosis (Alzheimer's disease, senile dementia) in long-livers of different climatic areas of the Republic of North Ossetia-Alania. New isoenzyme serum assays for determining creatine kinase BB-isoenzyme and the transaminase activity in the spinal fluid are proposed, which may be used as potential markers in the biochemical diagnosis of Alzheimer's disease. They can both provide valuable information on the severity of morphological lesions of cerebral cells in Alzheimer's disease and serve as the basis for the differential diagnosis of different forms of dementia wherein dystrophic changes in CNS cells are absent or slightly pronounced.

• Authors: K M Kozyrev, S P Siatkin, T T Berezov
• Journal: Vestnik Rossiiskoi akademii meditsinskikh nauk (Vestn Ross Akad Med Nauk) Issue 7 Pg. 3-9 ( 2002) ISSN: 0869-6047 [Print] Russia (Federation)
• Vernacular Title: Morfobiokhimicheskie osobennosti beta-amiloidozov u dolgozhiteleĭ.
• PMID: 12187538 (Publication Type: English Abstract, Journal Article)

Chemical References

• Biomarkers
• Isoenzymes
• Transaminases
• Creatine Kinase
• Creatine Kinase, BB Form

Topics

• Aged
• Aged, 80 and over
• Altitude
• Alzheimer Disease (cerebrospinal fluid, enzymology, pathology)
• Biomarkers (cerebrospinal fluid)
• Brain (enzymology, pathology)
• Creatine Kinase (cerebrospinal fluid)
• Creatine Kinase, BB Form
• Female
• Humans
• Isoenzymes (cerebrospinal fluid)
• Male
• Transaminases (cerebrospinal fluid)