L-nucleosides: antiviral activity and molecular mechanism.

Abstract

Drug discovery for antiviral chemotherapy has provided the effective treatment of numerous viral diseases. Among antiviral agents used in therapy, nucleoside analogues have been particularly useful. In fact, almost twenty nucleosides are currently used in antiviral therapy, seven of which are for the treatment of HIV infection. In the search for new and effective agents within this class, the focus has recently expanded on L-analogues, characterized by opposite configuration compared to the natural D-nucleosides. The interest in L-nucleosides has risen since the discovery of 3TC, one of the most important drugs used in the treatment of AIDS and hepatitis B infection. This review will discuss the latest advances in L-nucleosides as antiviral agents with a particular focus on the synthesis and molecular mechanism as well as metabolic differences between L- and D-nucleosides.

• Authors: Giuseppe Gumina, Youhoon Chong, Hyunah Choo, Gyu-Yong Song, Chung K Chu
• Journal: Current topics in medicinal chemistry (Curr Top Med Chem) Vol. 2 Issue 10 Pg. 1065-86 (Oct 2002) ISSN: 1568-0266 [Print] United Arab Emirates
• PMID: 12171513 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S., Review)

Chemical References

• Anti-HIV Agents
• Antiviral Agents
• Nucleosides

Topics

• Animals
• Anti-HIV Agents (chemistry, metabolism, pharmacology)
• Antiviral Agents (chemistry, metabolism, pharmacology)
• Biotransformation
• Humans
• Nucleosides (chemistry, metabolism, pharmacology)
• Phosphorylation
• Stereoisomerism
• Structure-Activity Relationship
• Virus Replication (drug effects)