[Effectiveness of vitamin A acid in diseases of the mouth mucosa: lichen ruber planus, leukoplakias and geographic tongue].

Abstract

52 patients, with different pattern of oral lichen planus, pre-malignant leukoplakia or geographic tongue, were treated with vitamin A acid. The systemic medication resulted in regression of discrete papules and leukoplakia-like appearance of oral lichen planus. Linear-hypertrophic pattern of the oral mucosa showed distinct involution only by topical administration of vitamin A acid. Also the patients suffering from pre-malignant leukoplakia or geographic tongue partly improved after a vitamin A acid therapy. Systemic side effects were noted after ignoring the tolerance limit (30 mg/day vitamin A acid/3 weeks). Inflammation and occasionally maceration appeared when local treatment was used over 3 weeks. Recurrence was observed in 11 patients.

• Authors: S Günther
• Journal: Zeitschrift fur Hautkrankheiten (Z Hautkr) Vol. 50 Issue 1 Pg. 41-6 (Jan 01 1975) ISSN: 0301-0481 [Print] Germany
• Vernacular Title: Uber Wirksamkeit der Vitamin-A-Säure bei Erkrankungen der Mundschleimhaut: Lichen ruber planus, Leukoplakien und Lingua geographica
• PMID: 1216954 (Publication Type: English Abstract, Journal Article)

Chemical References

• Vitamin A

Topics

• Administration, Oral
• Administration, Topical
• Female
• Glossitis, Benign Migratory (drug therapy)
• Humans
• Leukoplakia (drug therapy)
• Lichen Planus (drug therapy)
• Male
• Mouth Diseases (drug therapy)
• Vitamin A (administration & dosage, therapeutic use)