Pyogenic liver abscess: retrospective analysis of 80 cases over a 10-year period.

Abstract

BACKGROUND:

A total of 80 patients with pyogenic liver abscess managed at a single institution over a 10-year period were studied.

METHODS:

The clinical features, laboratory, imaging, and microbiologic findings, management strategy, and final outcome were studied.

RESULTS:

Fever and chills, leucocytosis and elevated alkaline phosphatase were the most common clinical and laboratory findings. Forty-one percent of patients were diabetic and 61% had biliary pathology. Systemic antibiotics and image-guided aspiration had a success rate of 94%. By multiple logistic regression analysis, malignancy on presentation (P = 0.011) was an independent risk factor associated with mortality. A past history of endoscopic sphincterotomy was an independent factor associated with resolution of liver abscess within 6 weeks (P = 0.03).

CONCLUSION:

Pyrexia, leucocytosis, elevated alkaline phosphatase, presence of diabetes, and underlying biliary pathology are common clinical and laboratory findings in patients with pyogenic liver abscess. Malignancy was associated with a poor outcome. Previous endoscopic sphincterotomy was a good prognostic factor for early resolution.

• Authors: Wai-Man Wong, Benjamin Chun Yu Wong, Chee Kin Hui, Matthew Ng, Kam Chuen Lai, Wai Kuen Tso, Shiu Kum Lam, Ching Lung Lai
• Journal: Journal of gastroenterology and hepatology (J Gastroenterol Hepatol) Vol. 17 Issue 9 Pg. 1001-7 (Sep 2002) ISSN: 0815-9319 [Print] Australia
• PMID: 12167122 (Publication Type: Journal Article)
• Copyright: Copyright 2002 Blackwell Publishing Asia Pty Ltd

Chemical References

• Anti-Bacterial Agents

Topics

• Adult
• Aged
• Aged, 80 and over
• Anti-Bacterial Agents (therapeutic use)
• Comorbidity
• Diabetes Complications
• Female
• Gram-Negative Bacterial Infections (microbiology, mortality, pathology, therapy)
• Gram-Positive Bacterial Infections (microbiology, mortality, pathology, therapy)
• Humans
• Liver Abscess (microbiology, mortality, pathology, therapy)
• Male
• Middle Aged
• Retrospective Studies
• Risk Factors
• Survival Rate
• Treatment Outcome