[Warfarin fetopathy].

Abstract

UNLABELLED:

We report a case of warfarin embryopathy. This disease affects more than 6% of fetuses exposed in utero to a vitamin K antagonist.

OBSERVATION:

A child whose mother was treated with acenocoumarol because of a mechanical heart valve presented with signs of warfarin embryopathy. He showed chondrodysplasia punctata with telebrachydactyly, facial dysmorphism with nasal hypoplasia, a cataract, and a bilateral pyeloureteral junction syndrome.

COMMENTS:

Characteristics of this drug induced embryopathy are reminded, while bearing in mind the conflict of interests between the mother and the fetus. The mechanisms of this embryopathy are debated in light of the recent knowledge concerning fetal metabolism of vitamin K.

• Authors: C Bony, F Zyka, I Tiran-Rajaofera, T Attali, S De Napoli, J L Alessandri
• Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie (Arch Pediatr) Vol. 9 Issue 7 Pg. 705-8 (Jul 2002) ISSN: 0929-693X [Print] France
• Vernacular Title: Foetopathie coumarinique.
• PMID: 12162160 (Publication Type: Case Reports, Comparative Study, English Abstract, Journal Article)

Chemical References

• Anticoagulants
• Warfarin
• Acenocoumarol

Topics

• Abnormalities, Drug-Induced (diagnosis, etiology)
• Acenocoumarol (adverse effects)
• Adult
• Age Factors
• Anticoagulants (adverse effects)
• Child, Preschool
• Chondrodysplasia Punctata (chemically induced)
• Female
• Fetus (drug effects)
• Follow-Up Studies
• Heart Valve Prosthesis
• Humans
• Infant
• Male
• Pregnancy
• Pregnancy Complications, Cardiovascular (drug therapy)
• Prenatal Exposure Delayed Effects
• Time Factors
• Warfarin (adverse effects)