HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Botulinum toxin A as a treatment for excessive drooling in children.

Abstract
Drooling is problematic for some neurologically impaired children. Botulinum toxin A injection to salivary glands has effectively reduced drooling in adults but has only recently been used to treat children. This was a preliminary study to determine the efficacy and safety of botulinum toxin in children. Children identified as having severe daily drooling were enrolled. The preinjection assessment included measurement of the amount and frequency of drool. Each parotid gland was injected with 5 U of botulinum toxin A. Follow-up was for a minimum of 16 weeks. Nine children were enrolled, 4-17 years of age. All children had moderate or severe mental retardation. At week 4, all patients had a reduced drooling frequency and eight of nine patients had a reduction in the weight of saliva. Overall, five of nine parents (55%) deemed the treatment successful. This preliminary study demonstrates that botulinum toxin A is a relatively effective treatment for some children with significant drooling without serious side effects.
AuthorsJ E Bothwell, K Clarke, J M Dooley, K E Gordon, R Anderson, E P Wood, C S Camfield, P R Camfield
JournalPediatric neurology (Pediatr Neurol) Vol. 27 Issue 1 Pg. 18-22 (Jul 2002) ISSN: 0887-8994 [Print] United States
PMID12160968 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Neuromuscular Agents
  • Botulinum Toxins, Type A
Topics
  • Adolescent
  • Botulinum Toxins, Type A (administration & dosage)
  • Cerebral Palsy (complications)
  • Child
  • Child, Preschool
  • Humans
  • Neuromuscular Agents (administration & dosage)
  • Parotid Gland
  • Sialorrhea (drug therapy, etiology)
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: