Hypersensitivity reactions to carboplatin in children.

Abstract

Hypersensitivity reactions to carboplatin are rare but sometimes life-threatening events may occur requiring discontinuation of treatment. In our study, we describe clinical features and diagnostic procedures of carboplatin-associated reactions in children affected by low-grade astrocytoma and treated with multiple courses of carboplatin. In 6 out of 29 children, we reported allergic events. We also report a desensitization protocol for carboplatin administration, which allowed the patients to receive effective treatment without adverse reactions.

• Authors: Ilaria Lazzareschi, Antonio Ruggiero, Riccardo Riccardi, Giorgio Attinà, Cesare Colosimo, Anna Lasorella
• Journal: Journal of neuro-oncology (J Neurooncol) Vol. 58 Issue 1 Pg. 33-7 (May 2002) ISSN: 0167-594X [Print] United States
• PMID: 12160138 (Publication Type: Journal Article)

Chemical References

• Anti-Allergic Agents
• Anti-Inflammatory Agents
• Antineoplastic Agents
• Chlorpheniramine
• Carboplatin
• Hydrocortisone
• Epinephrine

Topics

• Anti-Allergic Agents (therapeutic use)
• Anti-Inflammatory Agents (therapeutic use)
• Antineoplastic Agents (administration & dosage, adverse effects, therapeutic use)
• Astrocytoma (diagnosis, drug therapy)
• Brain Neoplasms (diagnosis, drug therapy)
• Carboplatin (administration & dosage, adverse effects, therapeutic use)
• Child, Preschool
• Chlorpheniramine (therapeutic use)
• Dose-Response Relationship, Drug
• Drug Hypersensitivity (drug therapy, etiology)
• Epinephrine (therapeutic use)
• Female
• Humans
• Hydrocortisone (therapeutic use)
• Infant
• Magnetic Resonance Imaging
• Male
• Treatment Outcome