Abstract | BACKGROUND: CASE DESCRIPTION: A patient with life-threatening hemispheric stroke was treated with moderate hypothermia (33 degrees C) that was maintained for 3 days, followed by a 3-day rewarming period. Microdialysis was applied to measure glutamate, lactate, and glycerol by using a microdialysis analyzer. FAEs were measured by microdialysis coupled with high-performance liquid chromatography/mass spectrometry. Release of neuroprotective fatty amides occurred within the first day after ischemia and reached high concentrations for all 3 substances in tissue surrounding the primary ischemic lesion: anandamide up to 42 pmol/mL, PEA up to 120 pmol/mL, and OEA up to 242 pmol/mL. There was a significant correlation with elevation of lactate as early marker for the hypoxic insult. CONCLUSIONS: This is the first report demonstrating release of FAEs in vivo during human stroke and may suggest contribution of the FAE signaling system to the pathophysiological events after ischemia.
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Authors | Wolf-R Schäbitz, Andrea Giuffrida, Christian Berger, Alfred Aschoff, Markus Schwaninger, Stefan Schwab, Daniele Piomelli |
Journal | Stroke
(Stroke)
Vol. 33
Issue 8
Pg. 2112-4
(Aug 2002)
ISSN: 1524-4628 [Electronic] United States |
PMID | 12154273
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Amides
- Arachidonic Acids
- Endocannabinoids
- Ethanolamines
- Oleic Acids
- Oleylethanolamide
- Palmitic Acids
- Polyunsaturated Alkamides
- Oleic Acid
- Lactic Acid
- Glutamic Acid
- palmidrol
- Glycerol
- anandamide
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Topics |
- Aged
- Amides
(chemistry)
- Arachidonic Acids
(analysis)
- Brain
(physiopathology)
- Brain Chemistry
- Brain Ischemia
(complications, diagnosis, metabolism, therapy)
- Endocannabinoids
- Ethanolamines
- Extracellular Space
(chemistry, metabolism)
- Glutamic Acid
(analysis)
- Glycerol
(analysis)
- Hemiplegia
(etiology)
- Humans
- Hypothermia, Induced
- Lactic Acid
(analysis)
- Male
- Microdialysis
- Monitoring, Physiologic
(instrumentation, methods)
- Oleic Acid
(analysis)
- Oleic Acids
- Palmitic Acids
(analysis)
- Polyunsaturated Alkamides
- Sleep Stages
- Stroke
(complications, diagnosis, metabolism, therapy)
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