Abstract | BACKGROUND: METHODS: In this multicenter, double-blinded, placebo-controlled study, women experiencing moderate-to-severe pain on the first day after abdominal hysterectomy or myomectomy received one intravenous dose of parecoxib sodium, 20 or 40 mg, ketorolac, 30 mg, morphine, 4 mg, or placebo. Analgesic efficacy and tolerability were evaluated for 24 h postdose or until patients, whose pain was not adequately controlled, opted to receive rescue analgesia. RESULTS: Two hundred two patients were enrolled. All treatment groups had comparable demographics and baseline pain status. All active treatments had an equally rapid time to onset of analgesia (10-23 min). Overall, each parecoxib sodium dose and ketorolac were significantly superior to morphine and placebo for most measures of analgesic efficacy at most time points, including a significantly longer (two- to threefold) time to rescue analgesia (P </= 0.05). All treatments were well tolerated. CONCLUSIONS:
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Authors | Scott F Barton, Fred F Langeland, Michael C Snabes, Diane LeComte, Michael E Kuss, Shobha S Dhadda, Richard C Hubbard |
Journal | Anesthesiology
(Anesthesiology)
Vol. 97
Issue 2
Pg. 306-14
(Aug 2002)
ISSN: 0003-3022 [Print] United States |
PMID | 12151917
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cyclooxygenase Inhibitors
- Isoxazoles
- Morphine
- parecoxib
- Ketorolac
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Topics |
- Adult
- Cyclooxygenase Inhibitors
(adverse effects, therapeutic use)
- Double-Blind Method
- Female
- Humans
- Hysterectomy
- Injections, Intravenous
- Isoxazoles
(adverse effects, therapeutic use)
- Ketorolac
(adverse effects, therapeutic use)
- Middle Aged
- Morphine
(therapeutic use)
- Pain Measurement
- Pain, Postoperative
(drug therapy)
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