Abstract | SETTING: The Singapore Tuberculosis (TB) Control Unit, a high volume national referral centre. OBJECTIVES: DESIGN: A retrospective review of adult patients started on TB treatment in 1998. RESULTS: There were 55 cases of DH in the cohort of 1036 patients treated in 1998. The median time to diagnosis of DH was 38 days. Factors significantly associated with DH were abnormal baseline transaminases/ bilirubin (OR 2.1, 95%CI 1.1-4.3, P = 0.02), age >60 years (OR 1.97, 95%CI 1.14-3.34, P = 0.01) and female sex (OR 1.9, 95%CI 1.07-3.4, P = 0.02). Ethnicity, self-reported alcohol consumption and body weight were not associated with development of DH. All three patients with fatal DH had received pyrazinamide-containing regimens. Treatment was re-introduced in 48 patients and successfully completed in 45 patients. The median time to reinstitution of TB treatment was 23 days. CONCLUSION:
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Authors | M D Teleman, C B E Chee, A Earnest, Y T Wang |
Journal | The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
(Int J Tuberc Lung Dis)
Vol. 6
Issue 8
Pg. 699-705
(Aug 2002)
ISSN: 1027-3719 [Print] France |
PMID | 12150482
(Publication Type: Journal Article)
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Chemical References |
- Antitubercular Agents
- Pyrazinamide
- Aspartate Aminotransferases
- Alanine Transaminase
- Bilirubin
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Topics |
- Alanine Transaminase
(blood)
- Antitubercular Agents
(adverse effects, therapeutic use)
- Aspartate Aminotransferases
(blood)
- Bilirubin
(blood)
- Chemical and Drug Induced Liver Injury
(epidemiology)
- Cohort Studies
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Pyrazinamide
(adverse effects, therapeutic use)
- Retrospective Studies
- Risk Factors
- Singapore
(epidemiology)
- Time Factors
- Tuberculosis, Pulmonary
(prevention & control)
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