Abstract | BACKGROUND: OBJECTIVE: A multi-centred, double-blind, placebo-controlled study was carried out in 155 children to evaluate chlorpheniramine in alleviating symptoms of AD. METHODS: Assessments were carried out over a 4-week study period consisting of 3 visits to out-patient clinics. During the visits the severity of AD and itching was rated using a series of visual analogue scale (VAS) and 5-point rating scales. RESULTS: The use of chlorpheniramine resulted in no greater alleviation of AD symptoms than placebo. CONCLUSIONS: The findings contradict conventional wisdom that the sedative effect of earlier-generation antihistamines alleviates symptoms of AD. The study also indicates that the use of antihistamines in AD does not affect the amounts of topical treatment used over the short term.
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Authors | J Munday, R Bloomfield, M Goldman, H Robey, G J Kitowska, Z Gwiezdziski, A Wankiewicz, R Marks, F Protas-Drozd, M Mikaszewska |
Journal | Dermatology (Basel, Switzerland)
(Dermatology)
Vol. 205
Issue 1
Pg. 40-5
( 2002)
ISSN: 1018-8665 [Print] Switzerland |
PMID | 12145433
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Copyright | Copyright 2002 S. Karger AG, Basel |
Chemical References |
- Antipruritics
- Emollients
- Histamine H1 Antagonists
- Chlorpheniramine
- Hydrocortisone
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Topics |
- Antipruritics
(adverse effects, therapeutic use)
- Child
- Child, Preschool
- Chlorpheniramine
(adverse effects, therapeutic use)
- Dermatitis, Atopic
(complications, drug therapy, pathology)
- Double-Blind Method
- Emollients
(administration & dosage)
- Female
- Histamine H1 Antagonists
(adverse effects, therapeutic use)
- Humans
- Hydrocortisone
(administration & dosage)
- Infant
- Male
- Pruritus
(complications, drug therapy, pathology)
- Skin
(pathology)
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