HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Role of lymphokines in immune response in respiratory viral infections].

Abstract
The present review deals with the analysis of lymphokine response in two main respiratory viral infections: influenza and respiratory syncytial (RS) infection. Immune response in these two diseases has great phenomenological differences. In particular, in RS infection the intensive response of macrophages and epithelial cells, accompanied mainly by the synthesis and secretion of tumor necrosis factor and interleukin 8, is observed. Due to this fact no protective immunity is formed in RS infection, in contrast to influenza. The specific features of immune and lymphokine response in RS infection make it difficult to develop protective vaccines. At the same time it is with RS infection that the development of chronic bronchopulmonary diseases is linked. The analysis of the role of lymphokine response in respiratory viral infections, particularly in influenza and RS infections, confirms the necessity of revising therapy both in the acute and subacute stages of these diseases.
AuthorsO I Kiselev, I A Vasil'eva, E B Chepik
JournalZhurnal mikrobiologii, epidemiologii i immunobiologii (Zh Mikrobiol Epidemiol Immunobiol) 2002 May-Jun Issue 3 Pg. 84-92 ISSN: 0372-9311 [Print] Russia (Federation)
Vernacular TitleRol' limfokinov v immunnom otvete pri respiratornykh virusnykh infektsiiakh.
PMID12141048 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • Interleukin-8
  • Lymphokines
  • Tumor Necrosis Factor-alpha
Topics
  • Bronchial Diseases (etiology)
  • Chronic Disease
  • Epithelial Cells (immunology)
  • Humans
  • Influenza, Human (immunology)
  • Interleukin-8 (analysis, biosynthesis)
  • Lymphokines (physiology)
  • Macrophages (immunology)
  • Respiratory Syncytial Virus Infections (complications, immunology)
  • Tumor Necrosis Factor-alpha (analysis, biosynthesis)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: