Abstract | BACKGROUND: OBJECTIVES: SEARCH STRATEGY: We searched the Cochrane Infectious Diseases Group specialized trials register (March 2002); the Cochrane Controlled Trials Register (The Cochrane Library, Issue 1, 2002); MEDLINE (1966 to March 2002); EMBASE (1988 to January 2002); LILACS (2001, 40a Edition CD-ROM). We checked references and contacted authors for additional data. SELECTION CRITERIA: DATA COLLECTION AND ANALYSIS: One reviewer screened the search results; both reviewers assessed eligibility, quality and extracted data. We used Review Manager (Version 4.1), and expressed results as Relative Risk (binary) or weighted mean difference (continuous), with 95% confidence intervals. MAIN RESULTS: Four trials involving 451 adults met the inclusion criteria. One small study did not demonstrate a difference between tetracycline with chloramphenicol (participants afebrile after 48 hours, Relative Risk 1.00; 95% confidence interval 0.07 to 15.26). Two small trials did not show a difference between doxycycline and tetracycline (participants afebrile after 48 hours, Relative Risk 0.46; 95% confidence interval 0.12 to 1.75). One trial showed rifampicin to be more effective than doxycycline (for eliminating fever, Relative Risk 0.41; 95% confidence interval 0.22 to 0.77; no relapses in either group). REVIEWER'S CONCLUSIONS:
|
Authors | R Panpanich, P Garner |
Journal | The Cochrane database of systematic reviews
(Cochrane Database Syst Rev)
Issue 3
Pg. CD002150
( 2002)
ISSN: 1469-493X [Electronic] England |
PMID | 12137646
(Publication Type: Journal Article, Review, Systematic Review)
|
Chemical References |
|
Topics |
- Adult
- Anti-Bacterial Agents
(therapeutic use)
- Humans
- Randomized Controlled Trials as Topic
- Scrub Typhus
(drug therapy)
|