Abstract | BACKGROUND: The mechanism of action of elemental diet in Crohn's disease treatment, is unknown. Alteration of bacterial flora, low antigenicity, low fat content and improvement of nutritional status are postulated to play a role in the anti-inflammatory effect of elemental diet. AIM: To determine whether elemental diet or its modifications has a direct anti-inflammatory effect on colonic tissue biopsies in vitro. PATIENTS AND METHODS: RESULTS: CONCLUSION: Elemental diet incubation increases anti-inflammatory:proinflammatory cytokine ratio in Crohn's disease and this anti-inflammatory effect is not specifically due to amino acid composition, as diets containing casein have similar anti-inflammatory effects.
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Authors | D Meister, J Bode, A Shand, S Ghosh |
Journal | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
(Dig Liver Dis)
Vol. 34
Issue 6
Pg. 430-8
(Jun 2002)
ISSN: 1590-8658 [Print] Netherlands |
PMID | 12132791
(Publication Type: Journal Article)
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Chemical References |
- Cytokines
- Interleukin-1
- Milk Proteins
- Receptors, Interleukin-1
- Interleukin-10
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Topics |
- Adolescent
- Adult
- Biopsy
- Case-Control Studies
- Crohn Disease
(diet therapy)
- Culture Techniques
- Cytokines
(biosynthesis)
- Enteral Nutrition
- Enzyme-Linked Immunosorbent Assay
- Food, Formulated
- Humans
- Interleukin-1
(metabolism)
- Interleukin-10
(metabolism)
- Middle Aged
- Milk Proteins
(therapeutic use)
- Receptors, Interleukin-1
(antagonists & inhibitors)
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