Treatment of a patient with hemophilia A and hepatitis C virus-related cirrhosis by living-related liver transplantation from an obligate carrier donor.

Abstract

BACKGROUND:

Decompensated hepatitis C virus (HCV)-related cirrhosis is the main indication for liver transplantation. We report the first successful living-related liver transplantation in a 49-year-old hemophilia A patient with end-stage HCV-related cirrhosis using a graft obtained from his 20-year-old daughter, an obligate carrier.

METHODS:

The donor's autologous fresh-frozen plasma rich in factor VIII (FVIII) by treatment with 1-deamino-8-D-arginine vasopressin was prepared before the operation. At induction, 1-deamino-8-D-arginine vasopressin was given to the donor to increase plasma FVIII level. In addition, autologous fresh-frozen plasma containing high FVIII concentrate was infused intraoperatively. The right lobe was harvested from the donor and transplanted orthotopically. The recipient was treated postoperatively with recombinant FVIII and immunosuppressive agents.

RESULTS:

The donor did not receive recombinant FVIII or allogenic blood during perioperative periods. No bleeding was encountered in the donor perioperatively. The recipient showed a steady increase in FVIII activity postoperatively and was discharged 40 days after transplantation. Ribavirin and interferon-alpha were provided for 3 months postoperatively to prevent potential recurrence of HCV infection. Serum HCV-RNA by RT-PCR became negative after such treatment.

CONCLUSIONS:

End-stage liver disease in patients with hemophilia A can be an indication for living-related liver transplantation. Furthermore, a graft from a living-related donor with hemophilia A carrier seems to be suitable provided such individuals receive adequate support for coagulopathies.

• Authors: Kohjiro Horita, Hidetoshi Matsunami, Yasunobu Shimizu, Akira Shimizu, Masaaki Kurimoto, Kohji Suzuki, Toshihisa Tsukadaira, Morio Arai
• Journal: Transplantation (Transplantation) Vol. 73 Issue 12 Pg. 1909-12 (Jun 27 2002) ISSN: 0041-1337 [Print] United States
• PMID: 12131686 (Publication Type: Case Reports, Journal Article)

Chemical References

• Factor VIII
• Deamino Arginine Vasopressin

Topics

• Deamino Arginine Vasopressin (therapeutic use)
• Factor VIII (administration & dosage)
• Hemophilia A (complications)
• Hepatitis C (complications)
• Humans
• Liver Cirrhosis (surgery)
• Liver Transplantation (methods)
• Male
• Middle Aged
• Tissue Donors