Abstract | PURPOSE:
Idiopathic retroperitoneal fibrosis is an uncommon disease of unknown etiology that may involve the ureters and other retroperitoneal structures. Surgical ureterolysis as well as medical treatment with steroids have been used to treat these patients. However, there is no agreement as to the dose and duration of steroid. We adopted a regimen of long-term steroid use in this prospective study. MATERIALS AND METHODS: RESULTS: Of the 12 patients 11 who completed this treatment regimen have been followed for a duration of 26 to 132 months (median 63.1) after discontinuation of treatment. Good response in the form of relief of symptoms and regression of the mass occurred in 9 cases and there were 2 failures. In 1 case the retroperitoneal mass did not regress and surgical ureterolysis was required. In the 2nd case symptoms recurred after discontinuation of steroid and a further small dose of steroids was required. Function deteriorated in 1 of 19 functioning renal units. No steroid related serious side effects developed. CONCLUSIONS:
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Authors | A H Kardar, S Kattan, E Lindstedt, K Hanash |
Journal | The Journal of urology
(J Urol)
Vol. 168
Issue 2
Pg. 550-5
(Aug 2002)
ISSN: 0022-5347 [Print] United States |
PMID | 12131307
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Biopsy
- Combined Modality Therapy
- Dose-Response Relationship, Drug
- Female
- Follow-Up Studies
- Humans
- Hydronephrosis
(drug therapy, pathology)
- Long-Term Care
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Nephrostomy, Percutaneous
- Prednisolone
(administration & dosage, adverse effects)
- Recurrence
- Retroperitoneal Fibrosis
(drug therapy, pathology)
- Retroperitoneal Space
(pathology)
- Stents
- Tomography, X-Ray Computed
- Treatment Outcome
- Ureteral Obstruction
(drug therapy, pathology)
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