Role of dietary phosphorus in the progression of renal failure.

Dietary phosphorus is thought to be a factor that impairs the residual renal function in patients with chronic renal failure. To determine the effect of dietary phosphorus on the prognosis of chronic renal failure, low-phosphorus milk was prepared from normal cow's milk using boehmite, a synthetic phosphate-ion absorbent. Regular diet, normal cow's milk, and low-phosphorus milk were then given to 5/6-nephrectomized rats and the serum levels of inorganic phosphorus, calcium, creatinine, and blood urine nitrogen in the rats in each group were compared. The serum levels of inorganic phosphorus and calcium were not different among the groups, despite a significant difference in phosphorus intakes. On the other hand, serum levels of creatinine (Cr) and blood urine nitrogen (BUN) in the rats fed low-phosphorus milk were significantly lower (Cr, 0.54+/-0.054mg/dl; BUN, 29.2+/-3.90mg/dl) than those in the rats fed a regular diet (Cr, 0.64+/-0.057mg/dl; BUN, 37.4+/-3.55mg/dl) or normal milk (Cr, 0.61+/-0.040mg/dl; BUN, 34.5+/-3.59mg/dl). No beneficial effect of protein restriction was observed when residual renal functions in rats fed a regular diet and those fed normal milk were compared. The results suggest that dietary phosphorus plays a major role in the progression of renal failure.
AuthorsTomohide Koizumi, Kazuya Murakami, Haruyuki Nakayama, Tomomi Kuwahara, Yoshinari Ohnishi
JournalBiochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 295 Issue 4 Pg. 917-21 (Jul 26 2002) ISSN: 0006-291X [Print] United States
PMID12127982 (Publication Type: Journal Article)
Chemical References
  • Dietary Proteins
  • Phosphates
  • Phosphorus
  • Creatinine
  • Nitrogen
  • Calcium
  • Animal Feed
  • Animals
  • Body Weight
  • Calcium (blood)
  • Creatinine (blood)
  • Dietary Proteins (administration & dosage)
  • Disease Progression
  • Male
  • Milk (metabolism)
  • Nitrogen (blood, metabolism, urine)
  • Phosphates (blood)
  • Phosphorus (metabolism)
  • Rats
  • Rats, Sprague-Dawley
  • Renal Insufficiency (diet therapy, etiology, metabolism)
  • Time Factors

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