Abstract |
We assessed evidence of the effects of secretin on behavior in individuals with autistic disorder. Articles were obtained through a MEDLINE search of the English-language literature from January 1966-November 2001; all investigations and case reports on the topic were included. Press releases obtained from the World Wide Web also were included. Secretin, a gastrointestinal hormone, is suggested to improve autistic symptoms, particularly social function and communication. Two formulations, porcine and synthetic human secretin, were evaluated in humans. A small body of literature and popular belief in autistic disorder communities supported the agent's efficacy. A number of controlled clinical trials did not show improvement in autistic symptoms with secretin compared with placebo, possibly indicating no role for the drug in autistic disorder.
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Authors | Nick C Patel, Jun Y Yeh, Marvin D Shepherd, M Lynn Crismon |
Journal | Pharmacotherapy
(Pharmacotherapy)
Vol. 22
Issue 7
Pg. 905-14
(Jul 2002)
ISSN: 0277-0008 [Print] United States |
PMID | 12126223
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Amino Acid Sequence
- Animals
- Autistic Disorder
(drug therapy, psychology)
- Clinical Trials as Topic
(statistics & numerical data)
- Humans
- Molecular Sequence Data
- Secretin
(physiology, therapeutic use)
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