Abstract | BACKGROUND & AIMS: METHODS: RESULTS: In the H. pylori-positive group, subjects with the proinflammatory IL-1B-511 T/T genotype had the highest atrophy and gastritis scores, the highest median gastric juice pH, and the lowest median serum PG I/PG II ratios. Although gastric juice pH significantly increased and serum PG I and PG I/PG II ratios significantly decreased in the IL-1B-511 T/T genotype group with age, no such age-dependent changes were observed in the C/C genotype group. Changes in the C/T genotype group were intermediate. In the H. pylori-negative group, the IL-1 loci had no effect on any of the physiologic or morphologic parameters. Carriage of IL-1RN allele 2 significantly protected against DU disease while the IL-1B-511 T/T genotype significantly protected against DU recurrence in patients older than 60 years. CONCLUSIONS: Proinflammatory IL-1beta polymorphisms are associated with hypochlorhydria and atrophic gastritis in Japan. The effects are dependent on H. pylori infection and become more significant with advancing age. This may explain the high incidence of gastric cancer in Japan and also the age-dependent decrease in DU recurrence in infected subjects.
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Authors | Takahisa Furuta, Emad M El-Omar, Fang Xiao, Naohito Shirai, Misako Takashima, Haruhiko Sugimura, Haruhiko Sugimurra |
Journal | Gastroenterology
(Gastroenterology)
Vol. 123
Issue 1
Pg. 92-105
(Jul 2002)
ISSN: 0016-5085 [Print] United States |
PMID | 12105837
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- IL1RN protein, human
- Interleukin 1 Receptor Antagonist Protein
- Interleukin-1
- Sialoglycoproteins
- Pepsinogen C
- Pepsinogen A
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Topics |
- Achlorhydria
(genetics)
- Alleles
- Asian People
(genetics)
- Duodenal Ulcer
(genetics)
- Female
- Gastric Juice
(chemistry)
- Gastritis, Atrophic
(genetics, metabolism, microbiology, pathology)
- Gene Frequency
- Genetic Predisposition to Disease
(genetics)
- Genotype
- Helicobacter pylori
(isolation & purification)
- Humans
- Hydrogen-Ion Concentration
- Interleukin 1 Receptor Antagonist Protein
- Interleukin-1
(genetics)
- Japan
- Male
- Middle Aged
- Pepsinogen A
(blood)
- Pepsinogen C
(blood)
- Peptic Ulcer
(genetics)
- Polymorphism, Genetic
- Recurrence
- Sialoglycoproteins
(genetics)
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