HBOC-201 improves survival in a swine model of hemorrhagic shock and liver injury.

Abstract

BACKGROUND:

Blunt abdominal trauma that leads to hemorrhagic shock and cardiac arrest is almost always fatal in the prehospital setting. The current study investigated whether a hemoglobin-based oxygen carrier (HBOC-201) could maintain organ viability during an exsanguinating liver injury and allow for prolonged survival. This hypothesis was tested in a large animal model that simulated blunt abdominal trauma with major organ injury.

METHODS:

Swine underwent a liver crush, laceration and 50 ml/kg initial blood loss. The liver bled at 3 ml/kg per min during the resuscitation phase. No fluid (NF=6), hetastarch (HES=8), or HBOC-201 (HBOC=8) was given during the resuscitation phase. Swine alive 60 min after the initial injury underwent liver repair and 96 h observation.

RESULTS:

All HBOC swine survived 60 min versus none of the NF or HES swine (P<0.05). All HBOC swine survived 24 h and 7/8 survived 96 h with good functional recovery.

CONCLUSIONS:

HBOC resuscitation during liver bleeding in a swine model of hemorrhagic shock and liver injury allowed for 96 h survival. No fluid or HES in the same model was fatal.

• Authors: Laurence M Katz, James E Manning, Shane McCurdy, L Bruce Pearce, Maria S Gawryl, Yuanfan Wang, Chad Brown, Carolina Resuscitation Research Group
• Journal: Resuscitation (Resuscitation) Vol. 54 Issue 1 Pg. 77-87 (Jul 2002) ISSN: 0300-9572 [Print] Ireland
• PMID: 12104112 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Blood Substitutes
• Hemoglobins
• Hydroxyethyl Starch Derivatives
• HBOC 201

Topics

• Animals
• Blood Pressure
• Blood Substitutes (administration & dosage, therapeutic use)
• Blood Volume
• Disease Models, Animal
• Hemoglobins (therapeutic use)
• Hydroxyethyl Starch Derivatives (administration & dosage)
• Liver (injuries, physiopathology, surgery)
• Resuscitation (methods)
• Shock, Hemorrhagic (therapy)
• Survival Analysis
• Swine