[Extracorporeal shock waves induce ventral-periosteal new bone formation out of the focus zone--results of an in-vivo animal trial].

It is known that high-energy extracorporeal shock waves, focussed to the intact distal rabbit femur, induce periosteal new bone formation within the focus zone. This study was done to investigate whether there is additionally new bone formation outside of the focus zone, i. e., in the proximal femur, 10 days after shock wave application to the distal rabbit femur.
18 adult Chinchilla-Bastard rabbits were randomly divided into three groups (A, B, C; each n = 6). One distal femur of each animal was focussed for shock wave application with different positive energy flux densities (A 1.2 mJ/mm (2), B 0.9 mJ/mm (2), C sham treatment). Only the proximal femur outside the shock wave focus was investigated. Here periosteal new bone formation was evaluated by fluorescent labelling. The maximum thickness was measured by means of computer-assisted image analysis.
Maximum ventral-periosteal new bone formation outside the shock wave focus was significantly increased in group A compared to group B (p = 0.007) or group C (p = 0.001). In contrast, the maximum ventral-periosteal new bone formation outside the shock wave focus demonstrated no statistically significant difference in group B compared to group C (p = 1.0).
Depending from the amount of positive energy flux density applied to distal rabbit femur a significantly increased ventral-periosteal new bone formation results in the proximal rabbit femur outside the shock wave focus.
AuthorsT Tischer, S Milz, H Anetzberger, P E Müller, D C Wirtz, C Schmitz, F Ueberle, M Maier
JournalZeitschrift für Orthopädie und ihre Grenzgebiete (Z Orthop Ihre Grenzgeb) 2002 May-Jun Vol. 140 Issue 3 Pg. 281-5 ISSN: 0044-3220 [Print] Germany
Vernacular TitleExtrakorporale Stosswellen induzieren ventral-periostale Knochenneubildung ausserhalb der Fokuszone - Ergebnisse einer In-vivo-Untersuchung am Tiermodell.
PMID12085293 (Publication Type: English Abstract, Journal Article)
  • Animals
  • Female
  • Femur (pathology)
  • Lithotripsy (adverse effects)
  • Microscopy, Fluorescence
  • Ossification, Heterotopic (pathology)
  • Periosteum (pathology)
  • Rabbits

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: