Association between serum apolipoprotein C(II) concentration and coronary heart disease.
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| Abstract | BACKGROUND:
Apolipoprotein (Apo) C(II) plays an essential role in the metabolism of triglyceride-rich lipoproteins (TRLs) by activating lipoprotein lipase. Several studies have suggested that an abnormal concentration of Apo C(II) may serve as a marker for deficient TRL metabolism, a possible cause of coronary heart disease (CHD). The aim of the present study was to evaluate the association between Apo C(II) and the presence of CHD. METHODS: A case-control study comparing 352 CHD patients and 395 controls was performed. Demographic, clinical, and laboratory characteristics were determined. RESULTS: The CHD patients had a higher mean concentration of Apo C(II) than controls (5.3 mg/dl compared with 4.2 mg/dl, P < 0.001). Elevated serum Apo C(II) concentration was associated with CHD presence after adjustment for cardiovascular risk factors. The risk factor-adjusted odds ratio (OR) for CHD was 1.60 (95% CI: 1.31-1.94) per 1 mg/dl increment in Apo C(II), compared with a risk factor-adjusted OR of 1.05 (95% CI: 0.85-1.32) per 40 mg/dl increment in triglyceride concentration. CONCLUSION: Increased serum concentration of Apo C(II) may represent a more sensitive marker of CHD than high serum concentration of triglycerides. Confirmation in cohort studies in required to establish or refute the role of elevated serum Apo C(II) as a risk factor for CHD.
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| Authors | Yariv Gerber, Uri Goldbourt, Hofit Cohen, Dror Harats |
| Journal | Preventive medicine (Prev Med) Vol. 35 Issue 1 Pg. 42-7 (Jul 2002) ISSN: 0091-7435 [Print] United States |
| PMID | 12079439 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't) |
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